The research of the OxyCat group, led by Frank Hollmann at Delft University of Technology, focuses on the establishment of new #redox chemistry using #biocatalysts.
One focus of the group lies on #oxyfunctionalisation reactions, i.e. oxidations where an oxygen atom is introduced into C-H-, C-C-, C=C-bonds. Performing these transformations selectively with traditional chemistry is notoriously difficult. A particular focus in the OxyCat group lies on Peroxygenases as #catalysts. These H2O2-dependent heme oxygenases excel by their robustness against hostile reaction conditions and their catalytic performance. Our objective is to develop reaction conditions allowing for their economical use. This entails, medium engineering to achieve product concentrations above 100 gL-1, reaction engineering to maximise the catalytic performance of the #biocatalyst and establish scalable 𝘪𝘯 𝘴𝘪𝘵𝘶 H2O2 generation systems.
Within the W-BioCat project, our focus will lie on the exploration of W-containing aldehyde oxidoreductases (AORs) for the #catalytic reduction of #carboxylic acids. In earlier studies, we have demonstrated the principal feasibility H2- or syngas-driven acid reductions using 𝑃𝑦𝑟𝑜𝑐𝑜𝑐𝑐𝑢𝑠 𝑓𝑢𝑟𝑖𝑜𝑠𝑢𝑠. The high selectivity of this reduction reaction and the controllable degree of reduction offers exciting possibilities for the valorisation of (waste) fatty acids as building blocks for chemical synthesis and as performance additives.
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